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Old 02-10-2013, 11:01 AM posted to alt.support.diabetes,misc.health.diabetes,alt.food.diabetic
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Default Melatonin Controls Weight Gain by Stimulating 'Beige Fat'

On 10/1/2013 9:19 AM, Ellen K. wrote:
This is very interesting. I eat almonds frequently and fennel (called
anise here) when it's not too expensive. Wonder if a melatonin
supplement would also help?


Probably, but salads with Goji berries, almonds, sunflower seeds,
cardamom, fennel, coriander and cherries would probably help more.
And taste better, probably.

Don Roberto


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...
Melatonin Controls Weight Gain by Stimulating 'Beige Fat'

Wed, 09/25/2013

Spanish scientists have discovered that melatonin consumption helps
control weight gain because it stimulates the appearance of ‘beige
fat,’ a type of fat cell that burns calories in vivo instead of
storing them.
Spanish scientists have discovered that melatonin consumption helps
control weight gain because it stimulates the appearance of ‘beige
fat,’ a type of fat cell that burns calories in vivo instead of
storing them.
Spanish scientists are the first to reveal the previously unknown
enigma of the effect melatonin has to counter obesity in the organism
and why it has metabolic benefits in treating diabetes and
hyperlipidemia.

Melatonin is a natural hormone segregated by the body and melatonin
levels generally increase in the dark at night. It is also found in
fruit and vegetables like mustard, Goji berries, almonds, sunflower
seeds, cardamom, fennel, coriander and cherries.

Spanish scientists have discovered that melatonin consumption helps
control weight gain because it stimulates the appearance of "beige
fat," a type of fat cell that burns calories in vivo instead of
storing them. White adipose tissue stores calories leading to weight
gain whereas "beige fat" (also known as "good or thinning fat") helps
regulate body weight control, hence its metabolic benefits.

In the Journal of Pineal Research, scientists from the University of
Granada Institute for Neuroscience, the Hospital Carlos III, Madrid,
and the University of Texas Health Science Center in San Antonio (USA)
have revealed, for the first time, the previously unknown enigma of
why melatonin has metabolic benefits in treating diabetes and
hyperlipidemia.

In earlier publications, the researchers analyzed the effects of
melatonin on obesity, dyslipidemia, high blood pressure and type 2
diabetes mellitus associated with obesity in young obese diabetic
Zucker rats— an experimental model of metabolic syndrome.

In view of their most recent results, it seems the key lies in the
fact that chronic melatonin consumption not only induces the
appearance of "beige fat" in obese diabetic rats, but also increases
its presence in thin animals used as a control group. "Beige fat"
cells are found in scattered lentil-sized deposits beneath the
inguinal skin in obese diabetic Zucker rats.

Melatonin is a natural hormone segregated by the human body itself and
melatonin levels generally increase in the dark at night. It is also
found in small quantities in fruit and vegetables like mustard, Goji
berries, almonds, sunflower seeds, cardamom, fennel, coriander and
cherries. These findings, together with the pharmacologically safe
profile of melatonin, mean it is a potentially useful tool both in its
own right and to complement the treatment of obesity. Sleeping in the
dark and consuming these foodstuffs could help control weight gain and
prevent cardiovascular diseases associated with obesity and dyslipidemia.

The study—coordinated by University of Granada lecturer Ahmad
Agil—showed that chronic administration of melatonin sensitizes the
thermogenic effect of exposure to cold, heightens the thermogenic
effect of exercise and, therefore, constitutes excellent therapy
against obesity. The fact is that one of the key differences between
"beige fat," which appears when administering melatonin, and "white
fat," is that "beige fat" cell mitochondria express levels of UCP1
protein, responsible for burning calories and generating heat.

The study—authored by Aroa Jiménez-Aranda, Gumersindo
Fernández-Vázquez, Daniel Campos, Mohamed Tassi, Lourdes
Velasco-Perez, Tx Tan, Russel Reiter and Ahmad Agil has been
part-financed and supported by the Granada Research of Excellence
Initiative on BioHealth (GREIB), the University of Granada
Vice-Rectorate for Scientific Policy and Research, and the regional
government of Andalusia research group CTS-109.

Given the importance of this discovery, the researchers are confident
they will obtain the funding needed to continue their work “and be
able to achieve their final objective: to confirm these findings in
humans, by administering melatonin to help combat obesity and
diabetes," says principle researcher Agil.

Source: University of Grenada




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