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Old 13-03-2013, 05:17 PM posted to soc.culture.indian,alt.fan.jai-maharaj,sci.med,alt.food.vegan,soc.culture.usa,alt.politics,talk.politics.misc
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Default Bitter melon juice may prevent pancreatic cancer

Bitter melon juice may prevent pancreatic cancer

PTI
The Hindu
Wednesday, March 13, 2013

Washington - Scientists have discovered that juice from
bitter melon also known as bitter gourd or ‘karela’, used
for centuries against diabetes in the folk medicines of
India and China, can prevent pancreatic cancer.

Researchers from the University of Colorado, Denver,
found that bitter melon juice restricts the ability of
pancreatic cancer cells to metabolise glucose, cutting
the cells’ energy source and eventually killing them in
mouse models.

“Three years ago researchers showed the effect of bitter
melon extract on breast cancer cells only in a Petri
dish. This study goes much, much farther,” said Rajesh
Agarwal, co-programme leader of Cancer Prevention and
Control at the CU Cancer Centre and professor at the
Skaggs School of Pharmacy and Pharmaceutical Sciences.

“We used the juice — people especially in Asian countries
are already consuming it in quantity — to show that it
affects the glucose metabolism pathway to restrict energy
and kill pancreatic cancer cells,” Agarwal said.

Agarwal’s interest came from connecting the dots of
existing research in a novel way. Diabetes tends to
presage pancreatic cancer and bitter melon has been shown
to effect type-II diabetes, and has been used for
centuries in China and India.

Following this line of thinking, Agarwal and colleagues
wondered what would happen if they closed out the middle
man of diabetes and directly explored the link between
bitter melon and pancreatic cancer.

The result, Agarwal said, is, “alteration in metabolic
events in pancreatic cancer cells and an activation of
the AMP-activated protein kinase, an enzyme that
indicates low energy levels in the cells.”

Perhaps not coincidentally, bitter melon also regulates
insulin secretion by pancreatic beta cells. After studies
in cell cultures, the group showed that mouse models of
pancreatic cancer that were fed bitter melon juice were
60 per cent less likely to develop the disease than
controls.

“It’s a very exciting finding. Many researchers are
engineering new drugs to target cancer cells’ ability to
supply themselves with energy, and here we have a
naturally-occurring compound that may do just that,”
Agarwal said in a statement.

The study was published in the journal Carcinogenesis.

Keywords: Diabetes,*bitter gourd juice,*pancreatic cancer

More at:

http://www.thehindu.com/sci-tech/hea...cle4504912.ece

Jai Maharaj, Jyotishi
Om Shanti

http://groups.google.com/group/alt.fan.jai-maharaj

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