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aluminum cook were
http://zapatopi.net/afdb.html
In ,
Lucian Wischik > typed:
> "Peter Aitken" > wrote:
>> "Tanya Quinn" > wrote in message
>>> But some researchers think there is a link between aluminum and
>>> Alzheimer's - not proven though.
>> This notion has been thoroughly disproven.
>
> Really? My father's a research in alzheimer disease, and he doesn't
> let us use aluminum. He wrote an article on the subject:
>
> ***
>
> Alzheimer's-disease-like changes in tau protein processing:
> association with aluminium accumulation in brains of renal dialysis
> patients.
>
> Harrington CR, Wischik CM, McArthur FK, Taylor GA, Edwardson JA, Candy
> JM
>
> Lancet 1994 Apr 23;343(8904):993-7
>
> Tau protein is a major structural protein of the paired helical
> filaments (PHFs) found in both neuritic senile plaques and
> neurofibrillary tangles in Alzheimer's disease (AD). Senile plaques
> also contain amyloid beta protein (A beta). We did an immunochemical
> analysis of frontal cortex from 15 dialysis cases, 5 Alzheimer's
> disease patients, and 6 control cases to see whether AD-like changes
> in A beta deposition and tau protein were linked to aluminium
> accumulation. Dialysis patients were used because they are frequently
> exposed to increased levels of aluminium. 8 of the 15 dialysis cases
> had insoluble A beta, but there was no association between its
> presence and the accumulation of aluminium. However, we found AD-like
> changes in the processing of tau protein. In white matter, truncated
> tau protein in the PHF-core fraction and endogenously truncated tau in
> the supernatant fraction were both increased in association with
> aluminium accumulation in the brain. In grey matter, normal tau
> protein was depleted and insoluble hyperphosphorylated tau increased
> in association with aluminium concentration. Protease-resistant PHFs
> were present in grey matter in 2 dialysis cases, a frequency above
> that expected for AD in this age group. PHF-core tau in both grey and
> white matter correlated with decreased levels of normal tau protein in
> white matter. These findings are consistent with a role for aluminium
> in the development of AD-like pathology in patients subjected to
> prolonged aluminium exposure.
>
> See also comment in Lancet 1994 Apr 23;343(8904):989-90, Lancet 1994
> Jul 16;344(8916):204-5, Lancet 1994 Aug 13;344(8920):486
>
>
> --
> Lucian
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