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Julie Bove[_2_] Julie Bove[_2_] is offline
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Default Guar gum and metformin


"Todd" > wrote in message
...
> Hi All,
>
> You all probably already know that guar gum interferes with
> metformin, but in case you didn't:
>
> http://www.ncbi.nlm.nih.gov/pubmed/2722133
>
> Horm Metab Res. 1989 Feb;21(2):81-3.
> The influence of Guar gum on absorption of metformin from
> the gut in healthy volunteers.
>
> Gin H, Orgerie MB, Aubertin J.
>
> Clinique Médicale et des maladies infectieuses, Hôpital Pellegrin,
> Bordeaux, France.
>
> Abstract
>
> Dietary fibre and biproducts of some vegetable extracts (Guar etc.)
> are advocated to reduce postprandial hyperglycaemia but there is
> some evidence that these may disturb the absorption kinetics of
> orally administered drugs. The effect of Guar gum on the digestive
> absorption of metformin was tested in 6 healthy subjects given
> 1700 mg of metformin with a standardised meal. Metformin blood
> levels showed that when given together with Guar there was a
> reduction in the absorption rate over the first 6 hours. These
> findings suggest that combination therapy may diminish the
> anti-hyperglycaemic action of metformin.


Never heard that before but... Don't eat guar gum either. I think there is
some other thickener that has little to no carbs in it but not sure what it
is.