Dr. Jai Maharaj posted:
>
> > How fatty food triggers diabetes
> >
> > PTI
> > The Pioneer
> > Tuesday, August 16, 2011
> >
> > London - For the first time, scientists have discovered how fatty
> > food trips a genetic switch in the body that can trigger diabetes, a
> > finding they say could lead to a potential cure for the disease.
> >
> > In studies on mice and humans, a team of researchers at the Sanford-
> > Burnham Medical Research Institute in the US found that high-levels
> > of fat disrupted two key proteins that turn genes on and off.
> >
> > The "transcription factors" FOXA2 and HNF1A activate a pancreatic
> > enzyme that in healthy people prevents diabetes developing, the Daily
> > Mail reported.
> >
> > When the proteins stop working, the enzyme is shut down, which in
> > turn upsets the ability of insulin-secreting beta cells in the
> > pancreas to monitor blood sugar levels.
> >
> > Without this glucose sugar-sensing mechanism, blood sugar cannot be
> > regulated properly.
> >
> > The discovery, published in the journal Nature Medicine, helps
> > explain why Type 2 diabetes is so often linked to obesity and it
> > could also lead to a potential cure for the condition, the
> > researchers said.
> >
> > Study leader Dr Jamey Marth said, "Now that we know more fully how
> > states of over-nutrition can lead to Type 2 diabetes, we can see more
> > clearly how to intervene.
> >
> > "The identification of the molecular players in this pathway to
> > diabetes suggests new therapeutic targets and approaches towards
> > developing an effective preventative or perhaps curative treatment.
> > "This may be accomplished by beta cell gene therapy or by drugs that
> > interfere with this pathway in order to maintain normal beta cell
> > function."
> >
> > http://dailypioneer.com/361028/How-f...-diabetes.html
> >
> > More at:
> > http://www.dailypioneer.com
>
> Recipe for Diabetes: Too Much Protein, Fat
>
> Protein Worsens Insulin Resistance From High-Fat Diet
>
> By Daniel J. DeNoon
> WebMD Health News
> Reviewed by Elizabeth Klodas, MD, FACC
>
> April 7, 2009 - Too much "good" protein makes bad fats worse, new
> research suggests.
>
> A high-fat diet may lead to insulin resistance, a major step on the
> path to type 2 diabetes. But cutting back on fat may not help those
> who continue to eat too much protein, find Christopher Newgard, PhD,
> director of the Sarah Stedman Nutrition and Metabolism Center at Duke
> University, and colleagues.
>
> "There's not only fat in that hamburger but plenty of protein,"
> Newgard tells WebMD. "We are overconsuming calories composed of all
> the different macronutrients, and together they have harmful
> effects."
>
> When they began their studies, Newgard and colleagues weren't trying
> to give protein a bad name. They were just trying to find out how the
> metabolism of obese people differs from that of lean people.
>
> To do this, they collected vast amounts of information -- including
> high-tech lab tests on blood and urine samples -- from 74 healthy
> obese people and 67 healthy lean people.
>
> Unexpectedly, obese people had a distinct metabolic "signature"
> related to a particular subtype of amino acids called BCAA (branched-
> chain amino acids). About 20% of the protein in the typical American
> diet is made up of BCAAs.
>
> Lean people's bodies tend to make new proteins out of BCAAs. In obese
> people, Newgard and colleagues suggest, this process gets overloaded.
> Instead of making new protein, the BCAAs are diverted into a deviant
> pathway that leads to insulin resistance.
>
> Can too much protein really be bad? Yes -- at least in lab rats.
> Newgard's team fed rats all the high-fat food they wanted. Two other
> groups of rats got less food: either standard chow or chow enriched
> with fats and BCAAs.
>
> The rats on the BCAA/fat diet didn't eat as much food or gain as much
> weight as the rats on the high-fat diet -- but they became just as
> insulin resistant.
>
> "Under circumstances of overconsumption, not only does excess fat and
> carbohydrate have injurious effects, but also the protein component
> of the diet can lead to some of the co-morbidities of obesity,"
> Newgard says.
>
> Human studies will be needed to confirm the rat findings. But Ronald
> B. Goldberg, MD, director of the lipid disorders clinic at the
> University of Miami, says the findings could have major implications.
>
> "What they show is that the combination of high fat and protein might
> be what's important in developing insulin resistance," Goldberg tells
> WebMD. "The truth is that in Western diets we do eat a high-protein,
> high-fat diet. The stress previously has not been on the high-protein
> component."
>
> The Newgard study appears in the April 8 issue of the journal Cell
> Metabolism.
>
> More at:
> http://diabetes.webmd.com/news/20090...ch-protein-fat

How Excess Fat Affects Diabetes

There are three reasons to cut fat for diabetics. Learn the reasons
why fat is bad for diabetes in this free video from a nutritionist
specializing in diabetic diets.

http://www.ehow.com/video_4399501_ho...-diabetes.html

Jai Maharaj, Jyotishi
Om Shanti

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