"Erik Hornung" > wrote in message news:<VA2Lb.47606$Dm.4963@edtnps89>...
> Whooaa...do you have this post in an english version? I'm just
> kidding...didn't know after my original post that i'd be reading all this
> scientific information...head hurts.
>
> Maybe my dad is right. Everything seems to cause cancer, and everything
> seems to prevent cancer.
>
> Erik
>
>
> "Mark Lipton" > wrote in message
> ...
> >
> >
> > Roman Caesar wrote:
> >
> > > Folks,
> > >
> > > I think the overall point is that resveratrol mimics
> > > caloric restriction. Caloric restriction is well-known
> > > and has been studied for decades and definitely prolongs
> > > life in most/all living organisms that have Sirtuins
> > > that I have heard of. They even bred one without Sirtuins
> > > and caloric restriction failed to extend life. This is
> > > most definitely one of the major longevity gene/enzymes
> > > that's been discovered. No question about it. That
> > > Harvard and BioMol could pair it with Caloric restriction
> > > is good research.
> >
> > True, but be careful in equating the overall health benefits of
> > resveratrol (and even
> > more, red wine) to its activation of sirtuins alone. Resveratrol has
> > also been shown to
> > inhibit the activity of the transcription factor NF-kappa-B and to
> > inhibit the enzyme
> > endothelin-1. It may be that sirtuins are an "upstream" controller of
> multiple
> > biochemical pathways, but that remains to be demonstrated.
> > Additionally, there is ample
> > evidence to suggest that the health benefits accorded red wine are not
> > due to resveratrol
> > *alone*. As I previously said, the flavonol quercetin, also found in
> > wine, has been
> > shown to have its own fair share of beneficial health effects and there
> > is reason to
> > believe that wine may contain yet more small molecules that impart
> > health benefits. Even
> > alcohol has been found to impart some health benefits, though there are
> > certainly adverse
> > health effects also attributable to it. As I said before, it's a
> > complex issue.
> >

No question about it. I still drink 2 glasses of red wine each day of
the weekend; but I can't do that during the weekday because of the
social unacceptability at work. Taking a sealed flask of 4 oz's
mid-day would simply not fit in. This isn't Europe. It's prudish
America.

So for me, a resveratrol/quercetin combination pill would be great,
but only if the pill were properly made. Non-sealed gelcaps with
transparent skins are useless as are the manufacturing methods of
most resveratrol pill makers.

I actually think www.longevinex.com has the right approach for
how to make the Resveratrol pill. I'd be more than willing to take
one of those daily M-F, take a couple glasses a day of Pinot Noir
on the weekend, and supplement slightly on the weekdays in the
evenings with 2-3 oz's of my favorite red (which isn't Pinot Noir
and happens to be Merlot.)