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Old 28-08-2011, 04:21 AM posted to soc.culture.indian,alt.fan.jai-maharaj,alt.religion.hindu,alt.food.vegan,alt.support.diabetes
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Default HOW FATTY FOOD TRIGGERS DIABETES [Sanford-Burnham Medical Research Institute]

Dr. Jai Maharaj posted:

How fatty food triggers diabetes

PTI
The Pioneer
Tuesday, August 16, 2011

London - For the first time, scientists have discovered how fatty
food trips a genetic switch in the body that can trigger diabetes, a
finding they say could lead to a potential cure for the disease.

In studies on mice and humans, a team of researchers at the Sanford-
Burnham Medical Research Institute in the US found that high-levels
of fat disrupted two key proteins that turn genes on and off.

The "transcription factors" FOXA2 and HNF1A activate a pancreatic
enzyme that in healthy people prevents diabetes developing, the Daily
Mail reported.

When the proteins stop working, the enzyme is shut down, which in
turn upsets the ability of insulin-secreting beta cells in the
pancreas to monitor blood sugar levels.

Without this glucose sugar-sensing mechanism, blood sugar cannot be
regulated properly.

The discovery, published in the journal Nature Medicine, helps
explain why Type 2 diabetes is so often linked to obesity and it
could also lead to a potential cure for the condition, the
researchers said.

Study leader Dr Jamey Marth said, "Now that we know more fully how
states of over-nutrition can lead to Type 2 diabetes, we can see more
clearly how to intervene.

"The identification of the molecular players in this pathway to
diabetes suggests new therapeutic targets and approaches towards
developing an effective preventative or perhaps curative treatment.
"This may be accomplished by beta cell gene therapy or by drugs that
interfere with this pathway in order to maintain normal beta cell
function."

http://dailypioneer.com/361028/How-f...-diabetes.html

More at:
http://www.dailypioneer.com


Recipe for Diabetes: Too Much Protein, Fat

Protein Worsens Insulin Resistance From High-Fat Diet

By Daniel J. DeNoon
WebMD Health News
Reviewed by Elizabeth Klodas, MD, FACC

April 7, 2009 - Too much "good" protein makes bad fats worse, new
research suggests.

A high-fat diet may lead to insulin resistance, a major step on the
path to type 2 diabetes. But cutting back on fat may not help those
who continue to eat too much protein, find Christopher Newgard, PhD,
director of the Sarah Stedman Nutrition and Metabolism Center at Duke
University, and colleagues.

"There's not only fat in that hamburger but plenty of protein,"
Newgard tells WebMD. "We are overconsuming calories composed of all
the different macronutrients, and together they have harmful
effects."

When they began their studies, Newgard and colleagues weren't trying
to give protein a bad name. They were just trying to find out how the
metabolism of obese people differs from that of lean people.

To do this, they collected vast amounts of information -- including
high-tech lab tests on blood and urine samples -- from 74 healthy
obese people and 67 healthy lean people.

Unexpectedly, obese people had a distinct metabolic "signature"
related to a particular subtype of amino acids called BCAA (branched-
chain amino acids). About 20% of the protein in the typical American
diet is made up of BCAAs.

Lean people's bodies tend to make new proteins out of BCAAs. In obese
people, Newgard and colleagues suggest, this process gets overloaded.
Instead of making new protein, the BCAAs are diverted into a deviant
pathway that leads to insulin resistance.

Can too much protein really be bad? Yes -- at least in lab rats.
Newgard's team fed rats all the high-fat food they wanted. Two other
groups of rats got less food: either standard chow or chow enriched
with fats and BCAAs.

The rats on the BCAA/fat diet didn't eat as much food or gain as much
weight as the rats on the high-fat diet -- but they became just as
insulin resistant.

"Under circumstances of overconsumption, not only does excess fat and
carbohydrate have injurious effects, but also the protein component
of the diet can lead to some of the co-morbidities of obesity,"
Newgard says.

Human studies will be needed to confirm the rat findings. But Ronald
B. Goldberg, MD, director of the lipid disorders clinic at the
University of Miami, says the findings could have major implications.

"What they show is that the combination of high fat and protein might
be what's important in developing insulin resistance," Goldberg tells
WebMD. "The truth is that in Western diets we do eat a high-protein,
high-fat diet. The stress previously has not been on the high-protein
component."

The Newgard study appears in the April 8 issue of the journal Cell
Metabolism.

More at:
http://diabetes.webmd.com/news/20090...ch-protein-fat

Jai Maharaj, Jyotishi
Om Shanti

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