Dr. Jai Maharaj posted:
How fatty food triggers diabetes
Tuesday, August 16, 2011
London - For the first time, scientists have discovered how fatty
food trips a genetic switch in the body that can trigger diabetes, a
finding they say could lead to a potential cure for the disease.
In studies on mice and humans, a team of researchers at the Sanford-
Burnham Medical Research Institute in the US found that high-levels
of fat disrupted two key proteins that turn genes on and off.
The "transcription factors" FOXA2 and HNF1A activate a pancreatic
enzyme that in healthy people prevents diabetes developing, the Daily
When the proteins stop working, the enzyme is shut down, which in
turn upsets the ability of insulin-secreting beta cells in the
pancreas to monitor blood sugar levels.
Without this glucose sugar-sensing mechanism, blood sugar cannot be
The discovery, published in the journal Nature Medicine, helps
explain why Type 2 diabetes is so often linked to obesity and it
could also lead to a potential cure for the condition, the
Study leader Dr Jamey Marth said, "Now that we know more fully how
states of over-nutrition can lead to Type 2 diabetes, we can see more
clearly how to intervene.
"The identification of the molecular players in this pathway to
diabetes suggests new therapeutic targets and approaches towards
developing an effective preventative or perhaps curative treatment.
"This may be accomplished by beta cell gene therapy or by drugs that
interfere with this pathway in order to maintain normal beta cell
Recipe for Diabetes: Too Much Protein, Fat
Protein Worsens Insulin Resistance From High-Fat Diet
By Daniel J. DeNoon
WebMD Health News
Reviewed by Elizabeth Klodas, MD, FACC
April 7, 2009 - Too much "good" protein makes bad fats worse, new
A high-fat diet may lead to insulin resistance, a major step on the
path to type 2 diabetes. But cutting back on fat may not help those
who continue to eat too much protein, find Christopher Newgard, PhD,
director of the Sarah Stedman Nutrition and Metabolism Center at Duke
University, and colleagues.
"There's not only fat in that hamburger but plenty of protein,"
Newgard tells WebMD. "We are overconsuming calories composed of all
the different macronutrients, and together they have harmful
When they began their studies, Newgard and colleagues weren't trying
to give protein a bad name. They were just trying to find out how the
metabolism of obese people differs from that of lean people.
To do this, they collected vast amounts of information -- including
high-tech lab tests on blood and urine samples -- from 74 healthy
obese people and 67 healthy lean people.
Unexpectedly, obese people had a distinct metabolic "signature"
related to a particular subtype of amino acids called BCAA (branched-
chain amino acids). About 20% of the protein in the typical American
diet is made up of BCAAs.
Lean people's bodies tend to make new proteins out of BCAAs. In obese
people, Newgard and colleagues suggest, this process gets overloaded.
Instead of making new protein, the BCAAs are diverted into a deviant
pathway that leads to insulin resistance.
Can too much protein really be bad? Yes -- at least in lab rats.
Newgard's team fed rats all the high-fat food they wanted. Two other
groups of rats got less food: either standard chow or chow enriched
with fats and BCAAs.
The rats on the BCAA/fat diet didn't eat as much food or gain as much
weight as the rats on the high-fat diet -- but they became just as
"Under circumstances of overconsumption, not only does excess fat and
carbohydrate have injurious effects, but also the protein component
of the diet can lead to some of the co-morbidities of obesity,"
Human studies will be needed to confirm the rat findings. But Ronald
B. Goldberg, MD, director of the lipid disorders clinic at the
University of Miami, says the findings could have major implications.
"What they show is that the combination of high fat and protein might
be what's important in developing insulin resistance," Goldberg tells
WebMD. "The truth is that in Western diets we do eat a high-protein,
high-fat diet. The stress previously has not been on the high-protein
The Newgard study appears in the April 8 issue of the journal Cell
Jai Maharaj, Jyotishi
o Not for commercial use. Solely to be fairly used for the educational
purposes of research and open discussion. The contents of this post may not
have been authored by, and do not necessarily represent the opinion of the
poster. The contents are protected by copyright law and the exemption for
fair use of copyrighted works.
o If you send private e-mail to me, it will likely not be read,
considered or answered if it does not contain your full legal name, current
e-mail and postal addresses, and live-voice telephone number.
o Posted for information and discussion. Views expressed by others are
not necessarily those of the poster who may or may not have read the article.
FAIR USE NOTICE: This article may contain copyrighted material the use of
which may or may not have been specifically authorized by the copyright
owner. This material is being made available in efforts to advance the
understanding of environmental, political, human rights, economic,
democratic, scientific, social, and cultural, etc., issues. It is believed
that this constitutes a 'fair use' of any such copyrighted material as
provided for in section 107 of the US Copyright Law. In accordance with Title
17 U.S.C. Section 107, the material on this site is distributed without
profit to those who have expressed a prior interest in receiving the included
information for research, comment, discussion and educational purposes by
subscribing to USENET newsgroups or visiting web sites. For more information
go to: http://www.law.cornell.edu/uscode/17/107.shtml
If you wish to use copyrighted material from this article for purposes of
your own that go beyond 'fair use', you must obtain permission from the
Since newsgroup posts are being removed
by forgery by one or more net terrorists,
this post may be reposted several times.