Natural Vs Synthetic vitamins
On Sat, 16 Jan 2010 11:52:54 -0500, James Silverton wrote:
Phred wrote on Sat, 16 Jan 2010 15:48:00 GMT:
In article ,
in a previous thread which I have lost, hence this new one
Mark Thorson wrote:
The most important point that folks constantly fail to
that synthetic vitamins are useless.
How does your body know whether a molecule of vitamin C
was made by a plant or in a factory? They both have
all of the same atoms in all of the same place.
I don't know about vitamins as such, but IICR organic
chemistry from 50 years ago, compounds that exist in two
optically active forms (Dextro and Levo) are often (always?)
biased to one form in natural biological systems but are made
in equal amounts in lab processes unless such are designed to
produce the separate forms.
The two mirror forms of racemic compounds are known as
enantiomers and have identical properties except for the
rotation of plane polarised light. However, the racemate [the
1:1 mixture] often has different properties to the pure
enantiomers (different melting points and solubilities are
very common). In the present context it's worth noting that
pharmaceuticals may be available as a racemate or as the pure
enantiomer, which might have different potencies.
Enantiomers of each other often show different chemical
reactions with other substances that are also enantiomers.
Since many molecules in the body of living beings are
enantiomers themselves, there is often a marked difference in
the effects of two enantiomers on living beings. In drugs, for
example, the working substance is often one of two
enantiomers, while the other one is responsible for adverse
It worth noting that virtually all active forms of amino acids
are of the L-form (d-serine being a notable exception) and
most biologically relevant sugars are of the D-form.
Typically, the alternative form is inactive and sometimes even
toxic to living things.
[All of which goes to show that my memory has not yet
completely failed; and suggests that Andy may have had a good
point when talking about synthetic vitamins.]
All that is true and interesting but we should not get distracted from
the fact that truly generic drugs possess the same handedness as the
originals. The only real difference can be in the formulation of pills
which may dissolve at different rates.
I don't have any particular liking for multivitamins and have doubts
about their efficacy and even what they are supposed to achieve. The
same applies to plant extracts like Echinacea whose content of the named
active principle can vary over a vast range.
it seems to me that the FDA should have weighed in on this, but damned if i
can find it. (googling [natural vs synthetic vitamins] turns up mostly
arguments from parties with an obvious vested interest in saying synthetics
are the tool of the devil.) does anyone know?