http://www.iherb.com/glucomsm2.html

Glucosamine gets digested in the small intestine. The only glucosamine
in a person's joints is the glucosamine his body produces.
"ta" wrote in message
...
http://www.iherb.com/glucomsm2.html

"sgdunn" wrote in message
news:8r7yb.72080$xV6.29525@lakeread04...
Glucosamine gets digested in the small intestine. The only glucosamine
in a person's joints is the glucosamine his body produces.

Do you have a source handy to back this comment up?

thanks

"ta" wrote in message
...
http://www.iherb.com/glucomsm2.html

On 2003-11-30 15:51:37 -0500, "Dutch" said:
Do you have a source handy to back this comment up?

http://www.arthritis-glucosamine.net...-products.html for instance says that MSM isn't proven and may indeed be unsafe.

http://www.pdrhealth.com/drug_info/n...glu_0122.shtml explains about contraindications as well as 13 studies indicating that it's effective for osteo-arthritis. Specifically:

"Oral glucosamine appears to be capable of prompting the chondrocytes to secrete more GAGs. This knowledge, derived from animal and in vitro studies, has prompted clinical trials of glucosamine in osteoarthritis."

However, to address your question (from the above link):

"PHARMACOKINETICS

Pharmacokinetics of glucosamine are derived primarily from animal studies. About 90% of glucosamine administered orally as a glucosamine salt gets absorbed from the small intestine, and from there it is transported via the portal circulation to the liver. It appears that a significant fraction of the ingested glucosamine is catabolized by first-pass metabolism in the liver. Free glucosamine is not detected in the serum after oral intake, and it is not presently known how much of an ingested dose is taken up in the joints in humans. Some uptake in the articular cartilage is seen in animal studies."